Week 4 Thursday Night Football pits Arizona Cardinals and Seattle Seahawks at State Farm Stadium (Glendale, AZ). It’s a key divisional matchup in the NFC West with both teams looking to position themselves early in the playoff race. Kickoff: 8:15 p.m. ET (7:15 CT / 6:15 MT / 5:15 PT and Arizona time).
The national broadcast in the U.S. is exclusive to Amazon Prime Video; in local markets, there will also be an open signal (Phoenix and Seattle).
How to watch in the U.S.
It's a key NFC West divisional clash
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National TV/Streaming: Prime Video (pregame starting at 7:00 p.m. ET).
Local markets: Open signal on FOX 10 Phoenix and FOX 13 Seattle (KCPQ), plus Prime broadcast.
Radio (examples): Westwood One nationally; local team options.
How they arrive
Seattle Seahawks are on a roll with two recent wins and defensive reinforcements that are starting to show under coach Mike Macdonald.
Arizona Cardinals with Kyler Murray at the helm, look to protect home and respond after a competitive start.
Running back James Conner is out for the season due to injury.
Freshman Trey Benson takes on a larger role in the backfield, also valuable as a third-down receiver.
Keys to the game
1. Air battle vs. short trench: Seattle Seahawks have been solid against the run in 2025, so Benson’s volume could come on safety receptions and check-downs.
Murray’s pace: If the Arizona Cardinals quarterback imposes tempo and extends plays, it will open windows for his tight end Trey McBride, a piece that already punished Seattle in 2024.
3. Prime Time Details: It will be the Cardinals’ first all-star performance in 2025 and will sport special rivalry uniform: charged atmosphere in Glendale.
Line and trends (subject to change)
Sportsbooks rank Seattle as slight favorites (around -1.5).
Remember that the momios move in the hours leading up to the kickoff.
Attendee logistics
If you are going to the stadium, gates open 90 minutes early and the NFL’s clear bag policy applies. Arrive early for security and traffic.
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